FertilOvaplus FertilOvaplus is a dietary supplement formulated for reproductive health. FertilOvaplus™ supports women who may be having difficulty conceiving, as it can help promote regular ovarian function, support regular menstrual cycles and may help increase egg quality.             FertilOvaplus is especially beneficial to women suffering with polycystic ovary syndrome (PCOS). (8,9,10,11) Research has shown that Inositol improves the way the body uses insulin and promotes normal hormone levels, which in turn promotes regular menstrual cycles and normal ovulatory function. Recent studies have shown that taking a combination of Myo and D-Chiro-Inositol, in the body’s naturally occurring ratio of 40:1, is more beneficial than taking Myo or D-Chiro alone (5,6). Folic acid, the other ingredient in FertilOvaplus is a water-soluble vitamin belonging to the B-group vitamins Folic acid plays a key role in the metabolism of amino acids in the protein and fusion and recovery of chromosomes and therefore is a key factor for normal cell division and tissue growth. Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders affecting women of reproductive age. It is characterized by chronic anovulation, hyperandrogenism, and insulin resistance. It is the main cause of infertility due to the menstrual dysfunction and metabolic disorders. Women with PCOS also have an increased cardiovascular risk because of dyslipidemia and insulin resistance. So far, Myo-inositol (MI) and D-chiro-inositol, two inositol stereoisomers, have been proven to be effective in PCOS treatment. However, only MI has been shown to have beneficial effects on reproductive function, whereas the administration of MI/D-chiro-inositol, in the physiological plasma ratio (i.e., 40:1) ensures better clinical results, such as the reduction of insulin resistance, androgens’ blood levels, cardiovascular risk and regularization of menstrual cycle with spontaneous ovulation (1,7,8). Between 65- 80% of patients with PCOS have insulin resistance, where the response to insulin is sub-optimal.  This condition is thought to contribute to a number of other issues related to PCOS, such as metabolic syndrome, hormonal imbalance, androgenic symptoms and diabetes in pregnancy. PCOS patients have a higher risk than normal of developing the metabolic syndrome; a mix of conditions including weight gain, type 2 diabetes and dyslipidaemia.  Approximately one third to one half of all women and adolescent girls with PCOS have the metabolic syndrome.  A recent RCOG ‘green top’ guideline advises doctors to inform patients with PCOS of such long-term health consequences.  Such patients have considerable long-term health risks and the evidence for using FertilOvaplus™ in these patients is compelling. What is PCOS? Polycystic ovary syndrome is so-called because women with this condition usually have polycystic ovaries. The term describes ovaries that contain about twice the normal number of small cysts, which are usually no bigger than 8 mm each. They are located just below the surface of the ovaries and are egg-containing follicles that have not developed properly due to a number of hormonal abnormalities. Women with PCOS may also have one or more additional symptoms including:
  • reduced fertility – difficulty becoming pregnant
  • irregular periods or no periods / irregular ovulation or no ovulation
  • increased risk of developing diabetes or high blood pressure (pre-eclampsia) during pregnancy
  • weight problems – being overweight, rapid weight gain, difficulty losing weight
  • skin problems including oily skin, acne
  • unwanted facial or body hair (hirsutism) / thinning hair or hair loss (alopecia)
Polycystic ovary syndrome (PCOS) is very common, affecting 5–10 % of women. A larger group of women (~ 20%) have polycystic ovaries (PCO) without the other symptoms listed above. PCOS
  • affects millions of women in the UK and worldwide
  • runs in families
  • is one of the leading causes of fertility problems in women
  • if not properly managed, can lead to additional health problems in later life
  • can affect a woman’s appearance and self-esteem
PCOS affects women in different ways Some women may have few, mild symptoms while others may have a wider range of more severe symptoms. The symptoms usually start in adolescence, although some women do not develop them until their early to mid-twenties. Ingredients: Myo-Inositol, D-Chiro-Inositol, Maltodextrin, Flavour – Orange (Orange Flavourings, Starch), Silicon Dioxide, Sweetener Sucralose E955, Folic Acid.   Nutritional Information:   Av. Per Day (2 x Sachets)  *% RI Myo-Inositol               4000mg          — D-Chiro-Inositol         100mg            — Folic Acid                    400µg            200   % RI = Reference Intakes µg = microgramme, mg = milligramme Energy, protein, fat and carbohydrate content negligible.   References:
  1. Updates on the myo-inositol plus D-chiro-inositol combined therapy in polycystic ovary syndrome. Expert Rev. Clin. Pharmacol. 7(5), 623-631 (2014).
  2. The Rationale of the Myo-Inositol and D-Chiro-Inositol combined treatment for PCOS. S. Dinicola PhD, T.T.Y. Chiu PhD, V. Unfer MD, G. Carlomangno PhD and M. Bizzarri PhD, MD. Journal of Clinical Pharmacology (2014)
  3. Combining treatment with myo-inositol and D-chiro-inositol (40:1) is effective in restoring ovary function and metabolic balance in PCOS patients. G. Monastra, V. Unfer, A.H. Harrath and M. Bizzarri. Gynecol Endocrinol, Early Online: 1-9: (2016).
  4. A combined therapy with Myo-Inositol and D-Chiro-Inositol improves endocrine parameters and insulin resistance in PCOS young overweight women. Benelli, S.D. Ghianda, C. Di Cosmo and M. Tonacchera. Int. Journal of Endocrinology. Article ID 3204083, 5 pages. (2016).
  5. The combined therapy with myo-inositol and D-Chiro-Inositol reduces the risk of metabolic disease in PCIS overweight patients compared to myo-inositol supplementation alone. M. Nordio and E. Proietti. European review for Medical and Pharmacological Sciences. 16: 575-581. (2012)
  6. The combined therapy myo-inositol plus D-chiro-inositol is able to improve IVF outcomes. S. Colazingari, M. Treglia, R. Najjar and A. Bevilacqua. Arch Gynecol Obstet. 288: 1405-11 (2013).
  7. Myo-Inositol administration positively affects hyperinsulinemia and hormonal parameters in overweight patients with PCOS. A.D. Genazzani, C. Lanzoni, F. Ricchieri and V.M. Jasonni. Gyn. End. 24(3):139-44 (2008).
  8. Results from the International Consensus Conference on myo-inositol and D-chiro-inositol in Obstetrics and Gynaecology – assisted reproduction technology.  Bevilacqua, Carlomagno et alGynecol Endocrinol, 2015; Early online: 1-6
  9. Effects of myo-inositol in women with PCOS: a systematic review of randomised controlled trials Gynecological Endocrinology, 2012; Early Online 1–7
  10. Contribution of myo-inositol to reproduction, Papaleo et al, European Journal of Obstetrics & Gynecology and Reproductive Biology 147 (2009) 120–123
  11. Effects of myo-inositol on ovarian function and metabolic factors in women with PCOS: a randomized double blind placebo-controlled trial, Gerli et al, European Review for Medical and Pharmacological Sciences, 2003; 7: 151-159
  12. Ovulation induction with myo-inositol alone and in combination with clomiphene citrate in polycystic ovarian syndrome patients with insulin resistance, Kamenov et al, Gynecological Endocrinology 2015, Vol 31, – Issue 2, pp131-135
  13. Effects of myo-Inositol supplementation on oocyte’s quality in PCOS patients: a double blind trial, Ciotta et al, European Review for Medical and Pharmacological Sciences, 2011; 15: 509-514
  14. Follicular fluid and serum concentrations of myo-inositol in patients undergoing IVF: relationship with oocyte quality.  Chiu et al, Hum Rep 2002, vol17, No 6, pp 1591 – 1596,
  15. Pre-treatment with myo-inositol in non-polycystic ovary syndrome patients undergoing multiple follicular stimulation for IVF: a pilot study, Lisi et al, Reproductive Biology and Endocrinology 2012,10:52
  16. Myo-inositol in patients with polycystic ovary syndrome: A novel method for ovulation induction, Papaleo et al, Gynecological Endocrinology, December 2007; 23(12): 700–703
  17. Long Term Consequences of Polycystic Ovary Syndrome, RCOG Green-top Guideline No 33, November 2014
  18. Metabolic syndrome and polycystic ovary syndrome… and vice versa, Kandaraki et al, Arq Bras Endocrinol Metab. 2009; 53/2
  19. The metabolic syndrome in polycystic ovary syndrome.  Essah PA1, Wickham EPNestler JEClin Obstet Gynecol.2007 Mar;50(1):205-25.
  20. Effects of Myo-inositol Supplementation in Postmenopausal Women with Metabolic Syndrome: A Prospective, Randomized, Placebo controlled Study, Giordano et al, Menopause, 2011;18(1):102-104.
  21. Costantino D et al, Metabolic and hormonal effects of myo-inositol in women with polycystic ovary syndrome: a double-blind trial. Eur Rev Med Pharm Sci 2009; 13: 105-110
  22. Gerli S, Papaleo E et al, Randomized, double blind placebo-controlled trial effects of Myo-inositol on ovarian function and metabolic factors in women with PCOS. Eur Rev Med & Pharm Sci 2007; 11: 347-354
  23. Artini P, Di Berardino O et al, Endocrine and clinical effects of myo-inositol administration in polycystic ovary syndrome – A randomised study optimised. Gynec Endoc, 2013; 29(4): 375-379
  24. Carlomagno G, Unfer V, Inositol safety – clinical evidences. Eur Rev Med & Pharm Sci 2011; 15: 931-936
  25. Donà G, Sabbadin C et al, Inositol administration reduces oxidative stress in erythrocytes of patients with polycystic ovary syndrome. Eur J of Endoc (2012) 166 703–710